PABA/NO as an Anticancer Lead: Analogue Synthesis, Structure Revision, Solution Chemistry, Reactivity toward Glutathione, and in Vitro Activity

PABA/NO is a diazeniumdiolate of structure Me(2)NN(O)=NOAr (where Ar is a 5-substituted-2,4-dinitrophenyl ring whose 5-substituent is N-methyl-p-aminobenzoic acid). It has shown activity against human ovarian cancer xenografts in mice rivaling that of cisplatin, but it is poorly soluble and relative...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Saavedra, Joseph E., Srinivasan, Aloka, Buzard, Gregory S., Davies, Keith M., Waterhouse, David J., Inami, Keiko, Wilde, Thomas C., Citro, Michael L., Cuellar, Matthew, Deschamps, Jeffrey R., Parrish, Damon, Shami, Paul J., Findlay, Victoria J., Townsend, Danyelle M., Tew, Kenneth D., Singh, Shivendra, Jia, Lee, Ji, Xinhua, Keefer, Larry K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522251/
https://ncbi.nlm.nih.gov/pubmed/16451080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm050700k
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados