PABA/NO as an Anticancer Lead: Analogue Synthesis, Structure Revision, Solution Chemistry, Reactivity toward Glutathione, and in Vitro Activity

PABA/NO is a diazeniumdiolate of structure Me(2)NN(O)=NOAr (where Ar is a 5-substituted-2,4-dinitrophenyl ring whose 5-substituent is N-methyl-p-aminobenzoic acid). It has shown activity against human ovarian cancer xenografts in mice rivaling that of cisplatin, but it is poorly soluble and relative...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Med Chem
Prif Awduron: Saavedra, Joseph E., Srinivasan, Aloka, Buzard, Gregory S., Davies, Keith M., Waterhouse, David J., Inami, Keiko, Wilde, Thomas C., Citro, Michael L., Cuellar, Matthew, Deschamps, Jeffrey R., Parrish, Damon, Shami, Paul J., Findlay, Victoria J., Townsend, Danyelle M., Tew, Kenneth D., Singh, Shivendra, Jia, Lee, Ji, Xinhua, Keefer, Larry K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2006
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522251/
https://ncbi.nlm.nih.gov/pubmed/16451080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm050700k
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