Combined genetic and epigenetic alterations of the TERT promoter affect clinical and biological behavior of bladder cancer

In urothelial bladder cancer (UBC), risk stratification remains an important unmet need. Limitless self‐renewal, governed by TERT expression and telomerase activation, is crucial for cancer progression. Thus, telomerase activation through the interplay of mutations (TERTp(Mut)) and epigenetic altera...

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Bibliographic Details
Published in:Int J Cancer
Main Authors: Leão, Ricardo, Lee, Donghyun, Figueiredo, Arnaldo, Hermanns, Thomas, Wild, Peter, Komosa, Martin, Lau, Irene, Mistry, Mathew, Nunes, Nuno Miguel, Price, Aryeh J., Zhang, Cindy, Lipman, Tatiana, Poyet, Cédric, Valtcheva, Nadejda, Oehl, Kathrin, Coelho, Hugo, Sayyid, Rashid, Gomes, Ana Melo, Prado e Castro, Ligia, Sweet, Joan, Vinagre, João, Apolónio, Joana, Stephens, Derek, Faleiro, Inês, Fadaak, Kamel, Richard, Patrick O., Kulkarni, Girish, Zlotta, Alexandre R., Hamilton, Robert J., Castelo‐Branco, Pedro, Tabori, Uri
Format: Artigo
Language:Inglês
Published: John Wiley & Sons, Inc. 2018
Subjects:
Tumor Markers and Signatures
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6519346/
https://ncbi.nlm.nih.gov/pubmed/30350309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.31935
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