DNA hypermethylation within TERT promoter upregulates TERT expression in cancer

Replicative immortality is a hallmark of cancer cells governed by telomere maintenance. Approximately 90% of human cancers maintain their telomeres by activating telomerase, driven by the transcriptional upregulation of telomerase reverse transcriptase (TERT). Although TERT promoter mutations (TPMs)...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Lee, Donghyun D., Leão, Ricardo, Komosa, Martin, Gallo, Marco, Zhang, Cindy H., Lipman, Tatiana, Remke, Marc, Heidari, Abolfazl, Nunes, Nuno Miguel, Apolónio, Joana D., Price, Aryeh J., De Mello, Ramon Andrade, Dias, João S., Huntsman, David, Hermanns, Thomas, Wild, Peter J., Vanner, Robert, Zadeh, Gelareh, Karamchandani, Jason, Das, Sunit, Taylor, Michael D., Hawkins, Cynthia E., Wasserman, Jonathan D., Figueiredo, Arnaldo, Hamilton, Robert J., Minden, Mark D., Wani, Khalida, Diplas, Bill, Yan, Hai, Aldape, Kenneth, Akbari, Mohammad R., Danesh, Arnavaz, Pugh, Trevor J., Dirks, Peter B., Castelo-Branco, Pedro, Tabori, Uri
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Concise Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307937/
https://ncbi.nlm.nih.gov/pubmed/30358567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI121303
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