DNA hypermethylation within TERT promoter upregulates TERT expression in cancer

Replicative immortality is a hallmark of cancer cells governed by telomere maintenance. Approximately 90% of human cancers maintain their telomeres by activating telomerase, driven by the transcriptional upregulation of telomerase reverse transcriptase (TERT). Although TERT promoter mutations (TPMs)...

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Vydáno v:J Clin Invest
Hlavní autoři: Lee, Donghyun D., Leão, Ricardo, Komosa, Martin, Gallo, Marco, Zhang, Cindy H., Lipman, Tatiana, Remke, Marc, Heidari, Abolfazl, Nunes, Nuno Miguel, Apolónio, Joana D., Price, Aryeh J., De Mello, Ramon Andrade, Dias, João S., Huntsman, David, Hermanns, Thomas, Wild, Peter J., Vanner, Robert, Zadeh, Gelareh, Karamchandani, Jason, Das, Sunit, Taylor, Michael D., Hawkins, Cynthia E., Wasserman, Jonathan D., Figueiredo, Arnaldo, Hamilton, Robert J., Minden, Mark D., Wani, Khalida, Diplas, Bill, Yan, Hai, Aldape, Kenneth, Akbari, Mohammad R., Danesh, Arnavaz, Pugh, Trevor J., Dirks, Peter B., Castelo-Branco, Pedro, Tabori, Uri
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Concise Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307937/
https://ncbi.nlm.nih.gov/pubmed/30358567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI121303
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