THOR METHYLATION PROVIDES INSIGHT INTO THE TELOMERE MAINTENANCE LANDSCAPE OF MALIGNANT GLIOMAS

BACKGROUND: Gliomas are a deadly group of childhood and adult cancers associated with high relapse rate following current therapies. Limitless self-renewal is a hallmark of cancer recurrence and is controlled by telomerase activation and telomere maintenance. We have recently uncovered THOR (TERT Hy...

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Detalhes bibliográficos
Main Authors: Tabori, Uri, Castelo-Branco, Pedro, Lee, Donghyun, Gallo, Marco, Limpan, Tatiana, Mangerel, Joshua, Price, Aryeh, Remke, Marc, Zhang, Cindy, Heidari, Abolfazl, Wani, Khalida, Vanner, Robert, Zadeh, Gelareh, Karamchandani, Jason, Das, Sunit, Taylor, michael, Hawkins, Cynthia, Yan, Hai, Aldape, Kenneth, Dirks, Peter B.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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abstracts
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144574/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou208.29
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