Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer

BACKGROUND: Limitless self-renewal is one of the hallmarks of cancer and is attained by telomere maintenance, essentially through telomerase (hTERT) activation. Transcriptional regulation of hTERT is believed to play a major role in telomerase activation in human cancers. MAIN BODY: The dominant int...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biomed Sci
Egile Nagusiak: Leão, Ricardo, Apolónio, Joana Dias, Lee, Donghyun, Figueiredo, Arnaldo, Tabori, Uri, Castelo-Branco, Pedro
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2018
Gaiak:
Review
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846307/
https://ncbi.nlm.nih.gov/pubmed/29526163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-018-0422-8
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