Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer

BACKGROUND: Limitless self-renewal is one of the hallmarks of cancer and is attained by telomere maintenance, essentially through telomerase (hTERT) activation. Transcriptional regulation of hTERT is believed to play a major role in telomerase activation in human cancers. MAIN BODY: The dominant int...

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Bibliographic Details
Published in:J Biomed Sci
Main Authors: Leão, Ricardo, Apolónio, Joana Dias, Lee, Donghyun, Figueiredo, Arnaldo, Tabori, Uri, Castelo-Branco, Pedro
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846307/
https://ncbi.nlm.nih.gov/pubmed/29526163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-018-0422-8
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