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Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer

BACKGROUND: Limitless self-renewal is one of the hallmarks of cancer and is attained by telomere maintenance, essentially through telomerase (hTERT) activation. Transcriptional regulation of hTERT is believed to play a major role in telomerase activation in human cancers. MAIN BODY: The dominant int...

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Foilsithe in:J Biomed Sci
Main Authors: Leão, Ricardo, Apolónio, Joana Dias, Lee, Donghyun, Figueiredo, Arnaldo, Tabori, Uri, Castelo-Branco, Pedro
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846307/
https://ncbi.nlm.nih.gov/pubmed/29526163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-018-0422-8
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