Combined genetic and epigenetic alterations of the TERT promoter affect clinical and biological behavior of bladder cancer

In urothelial bladder cancer (UBC), risk stratification remains an important unmet need. Limitless self‐renewal, governed by TERT expression and telomerase activation, is crucial for cancer progression. Thus, telomerase activation through the interplay of mutations (TERTp(Mut)) and epigenetic altera...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Int J Cancer
Autori principali: Leão, Ricardo, Lee, Donghyun, Figueiredo, Arnaldo, Hermanns, Thomas, Wild, Peter, Komosa, Martin, Lau, Irene, Mistry, Mathew, Nunes, Nuno Miguel, Price, Aryeh J., Zhang, Cindy, Lipman, Tatiana, Poyet, Cédric, Valtcheva, Nadejda, Oehl, Kathrin, Coelho, Hugo, Sayyid, Rashid, Gomes, Ana Melo, Prado e Castro, Ligia, Sweet, Joan, Vinagre, João, Apolónio, Joana, Stephens, Derek, Faleiro, Inês, Fadaak, Kamel, Richard, Patrick O., Kulkarni, Girish, Zlotta, Alexandre R., Hamilton, Robert J., Castelo‐Branco, Pedro, Tabori, Uri
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Inc. 2018
Soggetti:
Tumor Markers and Signatures
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6519346/
https://ncbi.nlm.nih.gov/pubmed/30350309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.31935
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