Infused factor VIII–expressing platelets or megakaryocytes as a novel therapeutic strategy for hemophilia A

B-domainless factor VIII (FVIII) ectopically expressed in megakaryocytes (MKs) is stored in α granules of platelets (pFVIII) and is capable of restoring hemostasis in FVIII(null) mice, even in the presence of circulating inhibitors. However, our prior studies have shown that this ectopically express...

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Detaylı Bibliyografya
Yayımlandı:Blood Adv
Asıl Yazarlar: Lyde, Randolph B., Ahn, Hyun Sook, Vo, Karen K., Jarocha, Danuta J., Tkaczynski, John, Treffeisen, Elsa, Sullivan, Spencer K., Camire, Rodney M., Sabatino, Denise E., French, Deborah L., Poncz, Mortimer
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2019
Konular:
Thrombosis and Hemostasis
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6517653/
https://ncbi.nlm.nih.gov/pubmed/31036722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017007914
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