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Infused factor VIII–expressing platelets or megakaryocytes as a novel therapeutic strategy for hemophilia A
B-domainless factor VIII (FVIII) ectopically expressed in megakaryocytes (MKs) is stored in α granules of platelets (pFVIII) and is capable of restoring hemostasis in FVIII(null) mice, even in the presence of circulating inhibitors. However, our prior studies have shown that this ectopically express...
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| 出版年: | Blood Adv |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6517653/ https://ncbi.nlm.nih.gov/pubmed/31036722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017007914 |
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