Infused factor VIII–expressing platelets or megakaryocytes as a novel therapeutic strategy for hemophilia A

B-domainless factor VIII (FVIII) ectopically expressed in megakaryocytes (MKs) is stored in α granules of platelets (pFVIII) and is capable of restoring hemostasis in FVIII(null) mice, even in the presence of circulating inhibitors. However, our prior studies have shown that this ectopically express...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Blood Adv
Egile Nagusiak: Lyde, Randolph B., Ahn, Hyun Sook, Vo, Karen K., Jarocha, Danuta J., Tkaczynski, John, Treffeisen, Elsa, Sullivan, Spencer K., Camire, Rodney M., Sabatino, Denise E., French, Deborah L., Poncz, Mortimer
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2019
Gaiak:
Thrombosis and Hemostasis
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6517653/
https://ncbi.nlm.nih.gov/pubmed/31036722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017007914
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