Infused factor VIII–expressing platelets or megakaryocytes as a novel therapeutic strategy for hemophilia A

B-domainless factor VIII (FVIII) ectopically expressed in megakaryocytes (MKs) is stored in α granules of platelets (pFVIII) and is capable of restoring hemostasis in FVIII(null) mice, even in the presence of circulating inhibitors. However, our prior studies have shown that this ectopically express...

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Veröffentlicht in:Blood Adv
Hauptverfasser: Lyde, Randolph B., Ahn, Hyun Sook, Vo, Karen K., Jarocha, Danuta J., Tkaczynski, John, Treffeisen, Elsa, Sullivan, Spencer K., Camire, Rodney M., Sabatino, Denise E., French, Deborah L., Poncz, Mortimer
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2019
Schlagworte:
Thrombosis and Hemostasis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6517653/
https://ncbi.nlm.nih.gov/pubmed/31036722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017007914
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