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Structure–Activity Relationships of the Tetrapeptide Ac-His-Arg-(pI)DPhe-Tic-NH(2) at the Mouse Melanocortin Receptors: Modification at the (pI)DPhe Position Leads to mMC3R Versus mMC4R Selective Ligands

The five melanocortin receptors (MC1R–MC5R) are involved in numerous biological pathways, including steroidogenesis, pigmentation, and food intake. In particular, MC3R and MC4R knockout mice suggest that the MC3R and MC4R regulate energy homeostasis in a non-redundant manner. While MC4R-selective ag...

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Foilsithe in:	Molecules
Main Authors:	Schlasner, Katherine N., Ericson, Mark D., Doering, Skye R., Freeman, Katie T., Weinrich, Mary, Haskell-Luevano, Carrie
Formáid:	Artigo
Teanga:	Inglês
Foilsithe:	MDPI 2019
Ábhair:	Article
Rochtain Ar Líne:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6515519/ https://ncbi.nlm.nih.gov/pubmed/31013889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24081463
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Structure–Activity Relationships of the Tetrapeptide Ac-His-Arg-(pI)DPhe-Tic-NH(2) at the Mouse Melanocortin Receptors: Modification at the (pI)DPhe Position Leads to mMC3R Versus mMC4R Selective Ligands

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