The Ac-Trp-DPhe(p-I)-Arg-Trp-NH(2) 250-Fold Selective Melanocortin-4 Receptor (MC4R) Antagonist over the Melanocortin-3 Receptor (MC3R) Affects Energy Homeostasis in Male and Female Mice Differently

The melanocortin-4 receptor (MC4R) has been indicated as a therapeutic target for metabolic disorders such as anorexia, cachexia, and obesity. The current study investigates the in vivo effects on energy homeostasis of a 15 nM MC4R antagonist SKY2-23-7, Ac-Trp-DPhe(p-I)-Arg-Trp-NH(2), that is a 3,70...

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Vydáno v:ACS Chem Neurosci
Hlavní autoři: Lensing, Cody J., Adank, Danielle N., Doering, Skye R., Wilber, Stacey L., Andreasen, Amy, Schaub, Jay W., Xiang, Zhimin, Haskell-Luevano, Carrie
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687811/
https://ncbi.nlm.nih.gov/pubmed/27385405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.6b00156
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