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The Ac-Trp-DPhe(p-I)-Arg-Trp-NH(2) 250-Fold Selective Melanocortin-4 Receptor (MC4R) Antagonist over the Melanocortin-3 Receptor (MC3R) Affects Energy Homeostasis in Male and Female Mice Differently
The melanocortin-4 receptor (MC4R) has been indicated as a therapeutic target for metabolic disorders such as anorexia, cachexia, and obesity. The current study investigates the in vivo effects on energy homeostasis of a 15 nM MC4R antagonist SKY2-23-7, Ac-Trp-DPhe(p-I)-Arg-Trp-NH(2), that is a 3,70...
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| Vydáno v: | ACS Chem Neurosci |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5687811/ https://ncbi.nlm.nih.gov/pubmed/27385405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.6b00156 |
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