ATP-citrate lyase multimerization is required for coenzyme-A substrate binding and catalysis

ATP-citrate lyase (ACLY) is a major source of nucleocytosolic acetyl-CoA, a fundamental building block of carbon metabolism in eukaryotes. ACLY is aberrantly regulated in many cancers, cardiovascular disease, and metabolic disorders. However, the molecular mechanisms determining ACLY activity and fu...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Bazilevsky, Gleb A., Affronti, Hayley C., Wei, Xuepeng, Campbell, Sydney L., Wellen, Kathryn E., Marmorstein, Ronen
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
Matèries:
Enzymology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509486/
https://ncbi.nlm.nih.gov/pubmed/30877197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006685
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