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ATP-citrate lyase multimerization is required for coenzyme-A substrate binding and catalysis

ATP-citrate lyase (ACLY) is a major source of nucleocytosolic acetyl-CoA, a fundamental building block of carbon metabolism in eukaryotes. ACLY is aberrantly regulated in many cancers, cardiovascular disease, and metabolic disorders. However, the molecular mechanisms determining ACLY activity and fu...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Bazilevsky, Gleb A., Affronti, Hayley C., Wei, Xuepeng, Campbell, Sydney L., Wellen, Kathryn E., Marmorstein, Ronen
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509486/
https://ncbi.nlm.nih.gov/pubmed/30877197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006685
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