ATP-citrate lyase controls a glucose-to-acetate metabolic switch

Mechanisms of metabolic flexibility enable cells to survive under stressful conditions and can thwart therapeutic responses. Acetyl-CoA plays central roles in energy production, lipid metabolism, and epigenomic modifications. Here we show that upon genetic deletion of Acly, the gene coding for ATP-c...

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Pubblicato in:Cell Rep
Autori principali: Zhao, Steven, Torres, AnnMarie, Henry, Ryan A., Trefely, Sophie, Wallace, Martina, Lee, Joyce V., Carrer, Alessandro, Sengupta, Arjun, Campbell, Sydney L., Kuo, Yin-Ming, Frey, Alexander J., Meurs, Noah, Viola, John M., Blair, Ian A., Weljie, Aalim M., Metallo, Christian M., Snyder, Nathaniel W., Andrews, Andrew J., Wellen, Kathryn E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5175409/
https://ncbi.nlm.nih.gov/pubmed/27760311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.09.069
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