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ATP-citrate lyase multimerization is required for coenzyme-A substrate binding and catalysis
ATP-citrate lyase (ACLY) is a major source of nucleocytosolic acetyl-CoA, a fundamental building block of carbon metabolism in eukaryotes. ACLY is aberrantly regulated in many cancers, cardiovascular disease, and metabolic disorders. However, the molecular mechanisms determining ACLY activity and fu...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6509486/ https://ncbi.nlm.nih.gov/pubmed/30877197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006685 |
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