ATP-citrate lyase links cellular metabolism to histone acetylation

Histone acetylation in single cell eukaryotes relies on acetyl-CoA synthetase enzymes that utilize acetate to produce acetyl-CoA. Metazoans, however, use glucose as their main carbon source and have exposure to only low concentrations of extracellular acetate. We show that histone acetylation in mam...

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Библиографические подробности
Главные авторы: Wellen, Kathryn E., Hatzivassiliou, Georgia, Sachdeva, Uma M., Bui, Thi V., Cross, Justin R., Thompson, Craig B.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746744/
https://ncbi.nlm.nih.gov/pubmed/19461003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1164097
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