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ATP-citrate lyase links cellular metabolism to histone acetylation
Histone acetylation in single cell eukaryotes relies on acetyl-CoA synthetase enzymes that utilize acetate to produce acetyl-CoA. Metazoans, however, use glucose as their main carbon source and have exposure to only low concentrations of extracellular acetate. We show that histone acetylation in mam...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2746744/ https://ncbi.nlm.nih.gov/pubmed/19461003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1164097 |
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