ATP-citrate lyase links cellular metabolism to histone acetylation

Histone acetylation in single cell eukaryotes relies on acetyl-CoA synthetase enzymes that utilize acetate to produce acetyl-CoA. Metazoans, however, use glucose as their main carbon source and have exposure to only low concentrations of extracellular acetate. We show that histone acetylation in mam...

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Bibliografiske detaljer
Main Authors:	Wellen, Kathryn E., Hatzivassiliou, Georgia, Sachdeva, Uma M., Bui, Thi V., Cross, Justin R., Thompson, Craig B.
Format:	Artigo
Sprog:	Inglês
Udgivet:	2009
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2746744/ https://ncbi.nlm.nih.gov/pubmed/19461003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1164097
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ATP-citrate lyase links cellular metabolism to histone acetylation

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