Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease

Hepatic steatosis is a hallmark of nonalcoholic fatty liver disease (NAFLD) and is promoted by dysregulated de novo lipogenesis. ATP-citrate lyase (ACLY) is a crucial lipogenic enzyme that is up-regulated in individuals with NAFLD. A previous study has shown that acetylation of ACLY at Lys-540, Lys-...

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Vydáno v:J Biol Chem
Hlavní autoři: Guo, Liang, Guo, Ying-Ying, Li, Bai-Yu, Peng, Wan-Qiu, Chang, Xin-Xia, Gao, Xin, Tang, Qi-Qun
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6682731/
https://ncbi.nlm.nih.gov/pubmed/31197036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008708
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