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Identification of the Citrate-binding Site of Human ATP-Citrate Lyase Using X-ray Crystallography
ATP-citrate lyase (ACLY) catalyzes the conversion of citrate and CoA into acetyl-CoA and oxaloacetate, coupled with the hydrolysis of ATP. In humans, ACLY is the cytoplasmic enzyme linking energy metabolism from carbohydrates to the production of fatty acids. In situ proteolysis of full-length human...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2930740/ https://ncbi.nlm.nih.gov/pubmed/20558738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.078667 |
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