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mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis
mTORC2 phosphorylates AKT in a hydrophobic motif site that is a biomarker of insulin sensitivity. In brown adipocytes, mTORC2 regulates glucose and lipid metabolism, however the mechanism has been unclear because downstream AKT signaling appears unaffected by mTORC2 loss. Here, by applying immunoblo...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6989638/ https://ncbi.nlm.nih.gov/pubmed/31996678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14430-w |
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