Interaction between p53 N terminus and core domain regulates specific and nonspecific DNA binding

The p53 tumor suppressor is a sequence-specific DNA binding protein that activates gene transcription to regulate cell survival and proliferation. Dynamic control of p53 degradation and DNA binding in response to stress signals are critical for tumor suppression. The p53 N terminus (NT) contains two...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: He, Fan, Borcherds, Wade, Song, Tanjing, Wei, Xi, Das, Mousumi, Chen, Lihong, Daughdrill, Gary W., Chen, Jiandong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2019
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500136/
https://ncbi.nlm.nih.gov/pubmed/30988205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903077116
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