Interaction between p53 N terminus and core domain regulates specific and nonspecific DNA binding

The p53 tumor suppressor is a sequence-specific DNA binding protein that activates gene transcription to regulate cell survival and proliferation. Dynamic control of p53 degradation and DNA binding in response to stress signals are critical for tumor suppression. The p53 N terminus (NT) contains two...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: He, Fan, Borcherds, Wade, Song, Tanjing, Wei, Xi, Das, Mousumi, Chen, Lihong, Daughdrill, Gary W., Chen, Jiandong
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500136/
https://ncbi.nlm.nih.gov/pubmed/30988205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903077116
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