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Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding
The MDMX oncoprotein is an important regulator of tumor suppressor p53 activity during embryonic development. Despite sequence homology to the ubiquitin E3 ligase MDM2, MDMX depletion activates p53 without significant increase in p53 level, implicating a degradation-independent mechanism. We present...
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| Udgivet i: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4868482/ https://ncbi.nlm.nih.gov/pubmed/27114532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603838113 |
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