Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding

The MDMX oncoprotein is an important regulator of tumor suppressor p53 activity during embryonic development. Despite sequence homology to the ubiquitin E3 ligase MDM2, MDMX depletion activates p53 without significant increase in p53 level, implicating a degradation-independent mechanism. We present...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Wei, Xi, Wu, Shaofang, Song, Tanjing, Chen, Lihong, Gao, Ming, Borcherds, Wade, Daughdrill, Gary W., Chen, Jiandong
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2016
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868482/
https://ncbi.nlm.nih.gov/pubmed/27114532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603838113
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