Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding

The MDMX oncoprotein is an important regulator of tumor suppressor p53 activity during embryonic development. Despite sequence homology to the ubiquitin E3 ligase MDM2, MDMX depletion activates p53 without significant increase in p53 level, implicating a degradation-independent mechanism. We present...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Wei, Xi, Wu, Shaofang, Song, Tanjing, Chen, Lihong, Gao, Ming, Borcherds, Wade, Daughdrill, Gary W., Chen, Jiandong
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868482/
https://ncbi.nlm.nih.gov/pubmed/27114532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603838113
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