MDMX acidic domain inhibits p53 DNA binding in vivo and regulates tumorigenesis

The MDM2 homolog MDMX oncoprotein is indispensable for inhibition of p53 during normal embryonic development and malignant transformation, yet how MDMX harnesses p53 functions is unclear. In addition to a canonical N-terminal p53-binding domain, recent work suggests the central acidic domain of MDMX...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Huang, Qingling, Chen, Lihong, Yang, Leixiang, Xie, Xiaoling, Gan, Lin, Cleveland, John L., Chen, Jiandong
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2018
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899450/
https://ncbi.nlm.nih.gov/pubmed/29581299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719090115
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