MDMX acidic domain inhibits p53 DNA binding in vivo and regulates tumorigenesis

The MDM2 homolog MDMX oncoprotein is indispensable for inhibition of p53 during normal embryonic development and malignant transformation, yet how MDMX harnesses p53 functions is unclear. In addition to a canonical N-terminal p53-binding domain, recent work suggests the central acidic domain of MDMX...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Huang, Qingling, Chen, Lihong, Yang, Leixiang, Xie, Xiaoling, Gan, Lin, Cleveland, John L., Chen, Jiandong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2018
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899450/
https://ncbi.nlm.nih.gov/pubmed/29581299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719090115
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