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MDMX acidic domain inhibits p53 DNA binding in vivo and regulates tumorigenesis
The MDM2 homolog MDMX oncoprotein is indispensable for inhibition of p53 during normal embryonic development and malignant transformation, yet how MDMX harnesses p53 functions is unclear. In addition to a canonical N-terminal p53-binding domain, recent work suggests the central acidic domain of MDMX...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5899450/ https://ncbi.nlm.nih.gov/pubmed/29581299 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719090115 |
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