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MDMX regulation of p53 response to ribosomal stress

Ribosomal stress such as disruption of rRNA biogenesis activates p53 by release of ribosomal proteins from the nucleoli, which bind to MDM2 and inhibit p53 degradation. We found that p53 activation by ribosomal stress requires degradation of MDMX in an MDM2-dependent fashion. Tumor cells overexpress...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Gilkes, Daniele M, Chen, Lihong, Chen, Jiandong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2006
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1679771/
https://ncbi.nlm.nih.gov/pubmed/17110929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601424
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