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MDMX regulation of p53 response to ribosomal stress
Ribosomal stress such as disruption of rRNA biogenesis activates p53 by release of ribosomal proteins from the nucleoli, which bind to MDM2 and inhibit p53 degradation. We found that p53 activation by ribosomal stress requires degradation of MDMX in an MDM2-dependent fashion. Tumor cells overexpress...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2006
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1679771/ https://ncbi.nlm.nih.gov/pubmed/17110929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601424 |
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