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The Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53

The p53 tumor suppressor is highly responsive to different physiological stresses such as abnormal cell proliferation, nutrient deprivation, and DNA damage. Distinct signaling mechanisms have evolved to activate p53, which in turn modulate numerous pathways to enhance fitness and survival of the org...

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Библиографические подробности
Главный автор: Chen, Jiandong
Формат: Artigo
Язык:Inglês
Опубликовано: SAGE Publications 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494364/
https://ncbi.nlm.nih.gov/pubmed/23150760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601912454733
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