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p53 Regulation Goes Live—Mdm2 and MdmX Co-Star: Lessons Learned from Mouse Modeling

Classically, p53 is considered to be an overarching tumor suppressor gene, important in its role as a transcription factor for a number of genes critical for cell cycle arrest, apoptosis, and senescence. More recently, the scope of p53 function has been further broadened, with evidence emerging that...

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Библиографические подробности
Главные авторы: Tollini, Laura A., Zhang, Yanping
Формат: Artigo
Язык:Inglês
Опубликовано: SAGE Publications 2012
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494374/
https://ncbi.nlm.nih.gov/pubmed/23150755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601912454732
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