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Mouse modelling of the MDM2/MDMX−p53 signalling axis

It is evident that p53 activity is critical for tumour prevention and stress response through its transcriptional activation of genes affecting cellular senescence, apoptosis, cellular metabolism, and DNA repair. The regulation of p53 is highly complex, and MDM2 and MDMX are thought to be critical f...

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Pubblicato in:J Mol Cell Biol
Autori principali: Tackmann, Nicole R., Zhang, Yanping
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5907827/
https://ncbi.nlm.nih.gov/pubmed/28096294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjx006
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