Optimal Affinity Enhancement by a Conserved Flexible Linker Controls p53 Mimicry in MdmX

MdmX contains an intramolecular binding motif that mimics the binding of the p53 tumor suppressor. This intramolecular binding motif is connected to the p53 binding domain of MdmX by a conserved flexible linker that is 85 residues long. The sequence of this flexible linker has an identity of 51% bas...

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Détails bibliographiques
Publié dans:Biophys J
Auteurs principaux: Borcherds, Wade, Becker, Andreas, Chen, Lihong, Chen, Jiandong, Chemes, Lucía B., Daughdrill, Gary W.
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2017
Sujets:
Biophysical Letter
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5443996/
https://ncbi.nlm.nih.gov/pubmed/28487147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.04.017
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