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Optimal Affinity Enhancement by a Conserved Flexible Linker Controls p53 Mimicry in MdmX
MdmX contains an intramolecular binding motif that mimics the binding of the p53 tumor suppressor. This intramolecular binding motif is connected to the p53 binding domain of MdmX by a conserved flexible linker that is 85 residues long. The sequence of this flexible linker has an identity of 51% bas...
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| Publicado no: | Biophys J |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5443996/ https://ncbi.nlm.nih.gov/pubmed/28487147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.04.017 |
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