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α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53–MDM2/MDMX Protein–Protein Interactions
[Image: see text] The use of peptidomimetic scaffolds is a promising strategy for the inhibition of protein–protein interactions (PPIs). Herein, we demonstrate that sulfono-γ-AApeptides can be rationally designed to mimic the p53 α-helix and inhibit p53–MDM2 PPIs. The best inhibitor, with K(d) and I...
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| Yayımlandı: | J Med Chem |
|---|---|
| Asıl Yazarlar: | , , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Chemical
Society
2020
|
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7025332/ https://ncbi.nlm.nih.gov/pubmed/31971801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00993 |
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