Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding

The MDMX oncoprotein is an important regulator of tumor suppressor p53 activity during embryonic development. Despite sequence homology to the ubiquitin E3 ligase MDM2, MDMX depletion activates p53 without significant increase in p53 level, implicating a degradation-independent mechanism. We present...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Wei, Xi, Wu, Shaofang, Song, Tanjing, Chen, Lihong, Gao, Ming, Borcherds, Wade, Daughdrill, Gary W., Chen, Jiandong
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868482/
https://ncbi.nlm.nih.gov/pubmed/27114532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603838113
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