Interaction between p53 N terminus and core domain regulates specific and nonspecific DNA binding

The p53 tumor suppressor is a sequence-specific DNA binding protein that activates gene transcription to regulate cell survival and proliferation. Dynamic control of p53 degradation and DNA binding in response to stress signals are critical for tumor suppression. The p53 N terminus (NT) contains two...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: He, Fan, Borcherds, Wade, Song, Tanjing, Wei, Xi, Das, Mousumi, Chen, Lihong, Daughdrill, Gary W., Chen, Jiandong
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500136/
https://ncbi.nlm.nih.gov/pubmed/30988205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903077116
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