Interaction between p53 N terminus and core domain regulates specific and nonspecific DNA binding

The p53 tumor suppressor is a sequence-specific DNA binding protein that activates gene transcription to regulate cell survival and proliferation. Dynamic control of p53 degradation and DNA binding in response to stress signals are critical for tumor suppression. The p53 N terminus (NT) contains two...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: He, Fan, Borcherds, Wade, Song, Tanjing, Wei, Xi, Das, Mousumi, Chen, Lihong, Daughdrill, Gary W., Chen, Jiandong
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2019
Ábhair:
PNAS Plus
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500136/
https://ncbi.nlm.nih.gov/pubmed/30988205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903077116
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