Extent of constitutive histone H2AX phosphorylation on Ser‐139 varies in cells with different TP53 status

Abstract.  In response to DNA damage by genotoxic agents, histone H2AX is phosphorylated on Ser‐139. However, during the cell cycle, predominantly in S and G(2)M phase, histone H2AX is also phosphorylated in untreated normal and tumour cells. This constitutive H2AX phosphorylation is markedly reduce...

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Bibliographic Details
Published in:Cell Prolif
Main Authors: Tanaka, T., Kurose, A., Huang, X., Traganos, F., Dai, W., Darzynkiewicz, Z.
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2006
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496136/
https://ncbi.nlm.nih.gov/pubmed/16872365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2184.2006.00387.x
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