Extent of constitutive histone H2AX phosphorylation on Ser‐139 varies in cells with different TP53 status

Abstract.  In response to DNA damage by genotoxic agents, histone H2AX is phosphorylated on Ser‐139. However, during the cell cycle, predominantly in S and G(2)M phase, histone H2AX is also phosphorylated in untreated normal and tumour cells. This constitutive H2AX phosphorylation is markedly reduce...

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Publicat a:Cell Prolif
Autors principals: Tanaka, T., Kurose, A., Huang, X., Traganos, F., Dai, W., Darzynkiewicz, Z.
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2006
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496136/
https://ncbi.nlm.nih.gov/pubmed/16872365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2184.2006.00387.x
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