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Constitutive histone H2AX phosphorylation and ATM activation are strongly amplified during mitogenic stimulation of lymphocytes

Abstract.  Objectives: We recently postulated that constitutive activation of Ataxia Telangiectasia, Mutated (CAA) and constitutive histone H2AX phosphorylation (CHP) seen in cells not treated with genotoxic agents are the events triggered by DNA damage caused by endogenous reactive oxygen species (...

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Bibliographische Detailangaben
Hauptverfasser: Tanaka, T., Kajstura, M., Halicka, H. D., Traganos, F., Darzynkiewicz, Z.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3860878/
https://ncbi.nlm.nih.gov/pubmed/17227291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2184.2007.00417.x
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