Constitutive Histone H2AX Phosphorylation and ATM Activation, the Reporters of DNA Damage by Endogenous Oxidants

DNA in live cells undergoes continuous oxidative damage caused by metabolically generated endogenous as well as external oxidants and oxidant-inducers. The cumulative oxidative DNA damage is considered the key factor in aging and senescence while the effectiveness of anti-aging agents is often asses...

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Main Authors: Tanaka, Toshiki, Halicka, H. Dorota, Huang, Xuan, Traganos, Frank, Darzynkiewicz, Zbigniew
Format: Artigo
Jezik:Inglês
Izdano: 2006
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488278/
https://ncbi.nlm.nih.gov/pubmed/16940754
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