ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis

Abstract.  Damage that engenders DNA double‐strand breaks (DSBs) activates ataxia telangiectasia mutated (ATM) kinase through its auto‐ or trans‐phosphorylation on Ser1981 and activated ATM is one of the mediators of histone H2AX phosphorylation on Ser139. The present study was designed to explore:...

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Bibliographic Details
Published in:Cell Prolif
Main Authors: Tanaka, T., Kurose, A., Huang, X., Dai, W., Darzynkiewicz, Z.
Format: Artigo
Language:Inglês
Published: Blackwell Science Ltd 2006
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496121/
https://ncbi.nlm.nih.gov/pubmed/16426422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2184.2006.00364.x
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