Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel

G protein-gated inwardly rectifying potassium channel (GIRK) plays a key role in regulating neurotransmission. GIRK is opened by the direct binding of the G protein βγ subunit (Gβγ), which is released from the heterotrimeric G protein (Gαβγ) upon the activation of G protein-coupled receptors (GPCRs)...

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Publicado en:Nat Commun
Main Authors: Kano, Hanaho, Toyama, Yuki, Imai, Shunsuke, Iwahashi, Yuta, Mase, Yoko, Yokogawa, Mariko, Osawa, Masanori, Shimada, Ichio
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494913/
https://ncbi.nlm.nih.gov/pubmed/31043612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10038-x
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