Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel

G protein-gated inwardly rectifying potassium channel (GIRK) plays a key role in regulating neurotransmission. GIRK is opened by the direct binding of the G protein βγ subunit (Gβγ), which is released from the heterotrimeric G protein (Gαβγ) upon the activation of G protein-coupled receptors (GPCRs)...

Full description

Saved in:
Bibliographic Details
Published in:Nat Commun
Main Authors: Kano, Hanaho, Toyama, Yuki, Imai, Shunsuke, Iwahashi, Yuta, Mase, Yoko, Yokogawa, Mariko, Osawa, Masanori, Shimada, Ichio
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494913/
https://ncbi.nlm.nih.gov/pubmed/31043612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10038-x
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items