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Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel
G protein-gated inwardly rectifying potassium channel (GIRK) plays a key role in regulating neurotransmission. GIRK is opened by the direct binding of the G protein βγ subunit (Gβγ), which is released from the heterotrimeric G protein (Gαβγ) upon the activation of G protein-coupled receptors (GPCRs)...
Guardat en:
| Publicat a: | Nat Commun |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6494913/ https://ncbi.nlm.nih.gov/pubmed/31043612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10038-x |
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