NMR Analyses of the Gβγ Binding and Conformational Rearrangements of the Cytoplasmic Pore of G Protein-activated Inwardly Rectifying Potassium Channel 1 (GIRK1)

G protein-activated inwardly rectifying potassium channel (GIRK) plays crucial roles in regulating heart rate and neuronal excitability in eukaryotic cells. GIRK is activated by the direct binding of heterotrimeric G protein βγ subunits (Gβγ) upon stimulation of G protein-coupled receptors, such as...

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Bibliographische Detailangaben
Hauptverfasser: Yokogawa, Mariko, Osawa, Masanori, Takeuchi, Koh, Mase, Yoko, Shimada, Ichio
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023517/
https://ncbi.nlm.nih.gov/pubmed/21075842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.160754
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