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Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses
Heterotrimeric guanine-nucleotide-binding proteins (G proteins) serve as molecular switches in signalling pathways, by coupling the activation of cell surface receptors to intracellular responses. Mutations in the G protein α-subunit (Gα) that accelerate guanosine diphosphate (GDP) dissociation caus...
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| Publié dans: | Nat Commun |
|---|---|
| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5322562/ https://ncbi.nlm.nih.gov/pubmed/28223697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14523 |
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